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Reference set of Mycobacterium tuberculosis clinical strains: a tool for research and product development

Borrell, Sònia and Trauner, Andrej and Brites, Daniela and Rigouts, Leen and Loiseau, Chloe and Coscolla, Mireia and Niemann, Stefan and De Jong, Bouke and Yeboah-Manu, Dorothy and Kato-Maeda, Midori and Feldmann, Julia and Reinhard, Miriam and Beisel, Christian and Gagneux, Sebastien. (2019) Reference set of Mycobacterium tuberculosis clinical strains: a tool for research and product development. PLoS ONE, 14 (3). e0214088.

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Abstract

The Mycobacterium tuberculosis complex (MTBC) causes tuberculosis (TB) in humans and various other mammals. The human-adapted members of the MTBC comprise seven phylogenetic lineages that differ in their geographical distribution. There is growing evidence that this phylogeographic diversity modulates the outcome of TB infection and disease. For decades, TB research and development has focused on the two canonical MTBC laboratory strains H37Rv and Erdman, both of which belong to Lineage 4. Relying on only a few laboratory-adapted strains can be misleading as study results might not be directly transferrable to clinical settings where patients are infected with a diverse array of strains, including drug-resistant variants. Here, we argue for the need to expand TB research and development by incorporating the phylogenetic diversity of the MTBC. To facilitate such work, we have assembled a group of 20 genetically well-characterized clinical strains representing the seven known human-adapted MTBC lineages. With the "MTBC clinical strains reference set" we aim to provide a standardized resource for the TB community. We hope it will enable more direct comparisons between studies that explore the physiology of MTBC beyond the laboratory strains used thus far. We anticipate that detailed phenotypic analyses of this reference strain set will increase our understanding of TB biology and assist in the development of new control tools that are broadly effective.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Tuberculosis Research (Gagneux)
UniBasel Contributors:Borrell, Sonia and Trauner, Andrej and Brites, Daniela and Loiseau, Chloé Marie and Coscollá Devís, Mireia and Feldmann, Julia and Gagneux, Sebastien
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Public Library of Science
e-ISSN:1932-6203
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:01 Apr 2019 09:28
Deposited On:01 Apr 2019 09:28

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