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A systematic analysis of mutual effects of transportation noise and air pollution exposure on myocardial infarction mortality: a nationwide cohort study in Switzerland

Héritier, Harris and Vienneau, Danielle and Foraster, Maria and Eze, Ikenna C. and Schaffner, Emmanuel and de Hoogh, Kees and Thiesse, Laurie and Rudzik, Franziska and Habermacher, Manuel and Köpfli, Micha and Pieren, Reto and Brink, Mark and Cajochen, Christian and Wunderli, Jean Marc and Probst-Hensch, Nicole and Röösli, Martin. (2019) A systematic analysis of mutual effects of transportation noise and air pollution exposure on myocardial infarction mortality: a nationwide cohort study in Switzerland. European heart journal, 40 (7). pp. 598-603.

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Official URL: https://edoc.unibas.ch/69735/

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Abstract

The present study aimed to disentangle the risk of the three major transportation noise sources-road, railway, and aircraft traffic-and the air pollutants NO2 and PM2.5 on myocardial infarction (MI) mortality in Switzerland based on high quality/fine resolution exposure modelling.; We modelled long-term exposure to outdoor road traffic, railway, and aircraft noise levels, as well as NO2 and PM2.5 concentration for each address of the 4.40 million adults (>30 years) in the Swiss National Cohort (SNC). We investigated the association between transportation noise/air pollution exposure and death due to MI during the follow-up period 2000-08, by adjusting noise [Lden(Road), Lden(Railway), and Lden(Air)] estimates for NO2 and/or PM2.5 and vice versa by multipollutant Cox regression models considering potential confounders. Adjusting noise risk estimates of MI for NO2 and/or PM2.5 did not change the hazard ratios (HRs) per 10 dB increase in road traffic (without air pollution: 1.032, 95% CI: 1.014-1.051, adjusted for NO2 and PM2.5: 1.034, 95% CI: 1.014-1.055), railway traffic (1.020, 95% CI: 1.007-1.033 vs. 1.020, 95% CI: 1.007-1.033), and aircraft traffic noise (1.025, 95% CI: 1.006-1.045 vs. 1.025, 95% CI: 1.005-1.046). Conversely, noise adjusted HRs for air pollutants were lower than corresponding estimates without noise adjustment. Hazard ratio per 10 μg/m³ increase with and without noise adjustment were 1.024 (1.005-1.043) vs. 0.990 (0.965-1.016) for NO2 and 1.054 (1.013-1.093) vs. 1.019 (0.971-1.071) for PM2.5.; Our study suggests that transportation noise is associated with MI mortality, independent from air pollution. Air pollution studies not adequately adjusting for transportation noise exposure may overestimate the cardiovascular disease burden of air pollution.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:Héritier, Harris and Vienneau, Danielle and Foraster Pulido, Maria and Eze, Ikenna C. and Schaffner, Emmanuel and de Hoogh, Kees and Probst Hensch, Nicole and Röösli, Martin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Oxford University Press
ISSN:0195-668X
Note:Publication type according to Uni Basel Research Database: Journal article -- This is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal following peer review. The version of record Harris Héritier, Danielle Vienneau, Maria Foraster, Ikenna C Eze, Emmanuel Schaffner, Kees de Hoogh, Laurie Thiesse, Franziska Rudzik, Manuel Habermacher, Micha Köpfli, Reto Pieren, Mark Brink, Christian Cajochen, Jean Marc Wunderli, Nicole Probst-Hensch, Martin Röösli, A systematic analysis of mutual effects of transportation noise and air pollution exposure on myocardial infarction mortality: a nationwide cohort study in Switzerland, European Heart Journal, Volume 40, Issue 7, 14 February 2019, Pages 598–603, https://doi.org/10.1093/eurheartj/ehy650 is available online at: 10.1093/eurheartj/ehy650
Language:English
Language:English
Identification Number:
Last Modified:11 Sep 2019 09:54
Deposited On:12 Mar 2019 10:12

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