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Forced expiratory flows and volumes in intubated and paralyzed infants and children : normative data up to 5 years of age

von Ungern-Sternberg, Britta S. and Trachsel, Daniel and Erb, Thomas O. and Hammer, Jürg. (2009) Forced expiratory flows and volumes in intubated and paralyzed infants and children : normative data up to 5 years of age. Journal of applied physiology, Vol. 107, no. 1. pp. 105-111.

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Official URL: http://edoc.unibas.ch/dok/A5250256

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Abstract

Reference equations that express indexes obtained from forced expiratory maneuvers in relation to height and/or other independent variables are lacking for infants and children with artificial airways. The present study was performed to establish normative data of forced expiration by forced deflation in healthy intubated and paralyzed infants and children and to develop prediction equations in relation to height and to ulna length to enable pulmonary assessments in children whose height is difficult to measure. Measurements of forced and passive expiratory maneuvers after inflation to +40 cmH(2)O inspiratory pressure were prospectively obtained in 100 healthy anesthetized children from 0 to 5 yr of age. Linear regressions of log-transformed forced vital capacity (FVC) and maximum expiratory flow at 25% and 10% FVC (MEF(25) and MEF(10), respectively) obtained by forced deflation (-40 cmH(2)O airway opening pressure) and of analogous indexes obtained by passive deflation were used to develop prediction equations from height or ulna length. FVC was significantly dependent on age and height or ulna length. Prediction equations for FVC using height or ulna length were as follows: ln(FVC in ml) = -5.6 + 2.8 x ln(height in cm) and ln(FVC in ml) = 0.46 + 2.5 x ln(ulna length in cm). Younger subjects had a significantly steeper slope for FVC vs. height than the older age group. Normal reference data for forced expiratory maneuvers in intubated infants and children up to 5 yr of age will enable improved assessment of pulmonary dysfunction in acutely or chronically ventilator-dependent children. Using ulna length instead of height should facilitate respiratory assessment in ventilated children with spinal or joint deformities.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Anästhesiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Anästhesiologie
03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Pädiatrie (Frey)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Pädiatrie (Frey)
UniBasel Contributors:Trachsel, Daniel and Hammer, Jürg and Erb, Thomas O. and Trachsel, Daniel
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Physiological Society
ISSN:0161-7567
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Mar 2013 11:08
Deposited On:22 Mar 2012 13:37

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