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Association of long-term exposure to traffic-related PM; 10; with heart rate variability and heart rate dynamics in healthy subjects

Meier-Girard, Delphine and Delgado-Eckert, Edgar and Schaffner, Emmanuel and Schindler, Christian and Künzli, Nino and Adam, Martin and Pichot, Vincent and Kronenberg, Florian and Imboden, Medea and Frey, Urs and Probst-Hensch, Nicole. (2019) Association of long-term exposure to traffic-related PM; 10; with heart rate variability and heart rate dynamics in healthy subjects. Environment international, 125. pp. 107-116.

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Abstract

Epidemiological evidence on the influence of long-term exposure to traffic-related particulate matter (TPM; 10; ) on heart rate variability (HRV) is weak.; To evaluate the association of long-term exposure (10 years) with TPM; 10; on the regulation of the autonomic cardiovascular system and heart rate dynamics (HRD) in an aging general population, as well as potential modifying effects by the a priori selected factors sex, smoking status, obesity, and gene variation in selected glutathione S-transferases (GSTs).; We analyzed data from 1593 SAPALDIA cohort participants aged ≥ 50 years. For each participant, various HRV and HRD parameters were derived from 24-hour electrocardiogram recordings. Each parameter obtained was then used as the outcome variable in multivariable mixed linear regression models in order to evaluate the association with TPM; 10; . Potential modifying effects were assessed using interaction terms.; No association between long-term exposure to TPM; 10; and HRV/HRD was observed in the entire study population. However, HRD changes were found in subjects without cardiovascular morbidity and both HRD and HRV changes in non-obese subjects without cardiovascular morbidity. Subjects without cardiovascular morbidity with homozygous GSTM1 gene deletion appeared to be more susceptible to the effects of TPM; 10; .; This study suggests that long-term exposure to TPM; 10; triggers adverse changes in the regulation of the cardiovascular system. These adverse effects were more visible in the subjects without cardiovascular disease, in whom the overall relationship between TPM; 10; and HRV/HRD could not be masked by underlying morbidities and the potential counteracting effects of related drug treatments.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Biostatistics - Frequency Modelling (Schindler)
UniBasel Contributors:Schaffner, Emmanuel and Schindler, Christian and Künzli, Nino and Imboden, Medea and Probst Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0160-4120
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:06 Mar 2019 08:02
Deposited On:06 Mar 2019 08:02

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