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Cloning of a novel glutamate receptor subunit, GluR5 : expression in the nervous system during development

Bettler, B. and Boulter, J. and Hermans-Borgmeyer, I. and O'Shea-Greenfield, A. and Deneris, E. S. and Moll, C. and Borgmeyer, U. and Hollmann, M. and Heinemann, S.. (1990) Cloning of a novel glutamate receptor subunit, GluR5 : expression in the nervous system during development. Neuron, Vol. 5, H. 5. pp. 583-595.

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Official URL: http://edoc.unibas.ch/dok/A5262305

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Abstract

We have isolated cDNAs encoding a glutamate receptor subunit, designated GluR5, displaying 40%-41% amino acid identity with the kainate/AMPA receptor subunits GluR1, GluR2, GluR3, and GluR4. This level of sequence similarity is significantly below the approximately 70% intersubunit identity characteristic of kainate/AMPA receptors. The GluR5 protein forms homomeric ion channels in Xenopus oocytes that are weakly responsive to L-glutamate. The GluR5 gene is expressed in subsets of neurons throughout the developing and adult central and peripheral nervous systems. During embryogenesis, GluR5 transcripts are detected in areas of neuronal differentiation and synapse formation.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > Molecular Neurobiology Synaptic Plasticity (Bettler)
UniBasel Contributors:Bettler, Bernhard
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cell Press
ISSN:0896-6273
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:36

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