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Conceptual endophenotypes: A strategy to advance the impact of psychoneuroendocrinology in precision medicine

Hellhammer, Dirk and Meinlschmidt, Gunther and Pruessner, Jens C.. (2018) Conceptual endophenotypes: A strategy to advance the impact of psychoneuroendocrinology in precision medicine. Psychoneuroendocrinology, 89. pp. 147-160.

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Official URL: https://edoc.unibas.ch/69392/

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Abstract

Psychobiological research has generated a tremendous amount of findings on the psychological, neuroendocrine, molecular and environmental processes that are directly relevant for mental and physical health, but have overwhelmed our capacity to meaningfully absorb, integrate, and utilize this knowledge base. Here, we reflect about suitable strategies to improve the translational success of psychoneuroendocrinological research in the era of precision medicine. Following a strategy advocated by the National Research Council and the tradition of endophenotype-based research, we advance here a new approach, termed "conceptual endophenotypes". We define the contextual and formal criteria of conceptual endophenotypes, outline criteria for filtering and selecting information, and describe how conceptual endophenotypes can be validated and implemented at the bedside. As proof-of-concept, we describe some of our findings from research that has adopted this approach in the context of stress-related disorders. We argue that conceptual endophenotypes engineer a bridge between the bench and the bedside. This approach readily lends itself to being continuously developed and implemented. Recent methodological advances, including digital phenotyping, machine learning, grassroots collaboration, and a learning healthcare system, may accelerate the development and implementation of this conceptual endophenotype approach.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Psychosomatik > Psychosomatik (Schäfert)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Psychosomatik > Psychosomatik (Schäfert)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Epidemiologie (Lieb)
UniBasel Contributors:Meinlschmidt, Gunther
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Elsevier
ISSN:0306-4530
e-ISSN:1873-3360
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:18 Feb 2019 16:05
Deposited On:18 Feb 2019 16:05

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