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Presynaptic and postsynaptic localization of GABA(B) receptors in neurons of the rat retina

Koulen, P. and Malitschek, B. and Kuhn, R. and Bettler, B. and Wässle, H. and Brandstätter, J. H.. (1998) Presynaptic and postsynaptic localization of GABA(B) receptors in neurons of the rat retina. The European journal of neuroscience, 10 (4). pp. 1446-1456.

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Official URL: http://edoc.unibas.ch/dok/A5262290

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Abstract

The recently cloned GABA(B) receptors were localized in rat retina using specific antisera. Immunolabelling was detected in the inner and outer plexiform layers (IPL, OPL), and in a number of cells in the inner nuclear layer and the ganglion cell layer. Double-labelling experiments for GABA (gamma-aminobutyric acid) and GABA(B) receptors, respectively, demonstrated a co-localization in horizontal cells and amacrine cells. Electron microscopy showed that GABA(B) receptors of the OPL were localized presynaptically in horizontal cell processes invaginating into photoreceptor terminals. In the IPL, GABA(B) receptors were present presynaptically in amacrine cells, as well as postsynaptically in amacrine and ganglion cells. The postnatal development of GABA(B) receptors was also studied, and immunoreactivity was observed well before morphological and synaptic differentiation of retinal neurons. The present results suggest a presynaptic (autoreceptor) as well as postsynaptic role for GABA(B) receptors. In addition, the extrasynaptic localization of GABA(B) receptors could indicate a paracrine function of GABA in the retina.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > Molecular Neurobiology Synaptic Plasticity (Bettler)
UniBasel Contributors:Bettler, Bernhard
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Blackwell
ISSN:0953-816X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Jul 2016 07:27
Deposited On:22 Mar 2012 13:36

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