Time heterogeneous programs of vaccination awareness : modeling and analysis

We investigate the role of time heterogeneity of public health systems efforts in favoring the propensity of parents to vaccinate their newborns against a target childhood disease. The starting point of our investigation is the behavioral-epidemiology model proposed by d’Onofrio et al. (PLoS ONE 7:e45653, 2012), where the PHS effort was assumed to be constant. We also consider the co-presence of another layer of temporal heterogeneity: seasonality in the contact rate of the disease. We mainly assume that the effort is periodic with a 1-year period because of alternating working and holiday periods. We show that if the average effort is larger than a threshold, then the disease can be eliminated leading to an ideal equilibrium point with 100% of vaccinated newborns. A more realistic disease-free equilibrium can also be reached, under a condition that depends on the whole form of the time profile describing the PHS effort. We also generalize our disease elimination-related results to a wide class of time-heterogenous PHS efforts. Finally, we analytically show that if the disease elimination is not reached, then the disease remains uniformly persistent.