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Cryptococcal meningitis diagnostics and screening in the era of point-of-care laboratory testing

Rajasingham, Radha and Wake, Rachel M. and Beyene, Tafese and Katende, Andrew and Letang, Emilio and Boulware, David R.. (2019) Cryptococcal meningitis diagnostics and screening in the era of point-of-care laboratory testing. Journal of clinical microbiology, 57 (1). e01238-18.

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Official URL: https://edoc.unibas.ch/69180/

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Abstract

Over the past ten years, standard diagnostics for cryptococcal meningitis in HIV-infected persons have evolved from culture to India ink to detection of cryptococcal antigen (CrAg), with the recent development and distribution of a point-of-care lateral flow assay. This assay is highly sensitive and specific in cerebrospinal fluid (CSF), but is also sensitive in the blood to detect CrAg prior to meningitis symptoms. CrAg screening of HIV-infected persons in the blood prior to development of fulminant meningitis and preemptive treatment for CrAg-positive persons are recommended by the World Health Organization and many national HIV guidelines. Thus, CrAg testing is occurring more widely, especially in resource-limited laboratory settings. CrAg titer predicts meningitis and death and could be used in the future to customize therapy according to burden of infection.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Medicine > Clinical Research (Reither)
UniBasel Contributors:Letang Jimenez de Anta, Emilio Angel
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:0095-1137
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:26 Feb 2019 09:45
Deposited On:26 Feb 2019 09:45

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