Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages

Mizrak, Dogukan and Levitin, Hanna Mendes and Delgado, Ana C. and Crotet, Valerie and Yuan, Jinzhou and Chaker, Zayna and Silva-Vargas, Violeta and Sims, Peter A. and Doetsch, Fiona. (2019) Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages. Cell reports, 26 (2). pp. 394-406.e5.

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Official URL: https://edoc.unibas.ch/68639/

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The ventricular-subventricular zone (V-SVZ) harbors adult neural stem cells. V-SVZ neural stem cells exhibit features of astrocytes, have a regional identity, and depending on their location in the lateral or septal wall of the lateral ventricle, generate different types of neuronal and glial progeny. We performed large-scale single-cell RNA sequencing to provide a molecular atlas of cells from the lateral and septal adult V-SVZ of male and female mice. This revealed regional and sex differences among adult V-SVZ cells. We uncovered lineage potency bias at the single-cell level among lateral and septal wall astrocytes toward neurogenesis and oligodendrogenesis, respectively. Finally, we identified transcription factor co-expression modules marking key temporal steps in neurogenic and oligodendrocyte lineage progression. Our data suggest functionally important spatial diversity in neurogenesis and oligodendrogenesis in the adult brain and reveal molecular correlates of adult NSC dormancy and lineage specialization.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Stem Cell Biology (Doetsch)
UniBasel Contributors:Doetsch, Fiona and Delgado Fumero, Ana and Crotet, Valérie and Chaker, Zayna and Silva Vargas, Violeta
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:05 Aug 2020 15:17
Deposited On:05 Aug 2020 15:17

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