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Sex differences in cognitive functioning in at-risk mental state for psychosis, first episode psychosis and healthy control subjects

Ittig, Sarah and Studerus, Erich and Papmeyer, Martina and Uttinger, Martina and Koranyi, Susan and Ramyead, Avinash and Riecher-Rössler, Anita. (2015) Sex differences in cognitive functioning in at-risk mental state for psychosis, first episode psychosis and healthy control subjects. European Psychiatry, 30 (2). pp. 242-250.

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Official URL: https://edoc.unibas.ch/68328/

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Abstract

BACKGROUND: Several sex differences in schizophrenia have been reported including differences in cognitive functioning. Studies with schizophrenia patients and healthy controls (HC) indicate that the sex advantage for women in verbal domains is also present in schizophrenia patients. However, findings have been inconsistent. No study focused on sex-related cognitive performance differences in at-risk mental state for psychosis (ARMS) individuals yet. Thus, the aim of the present study was to investigate sex differences in cognitive functioning in ARMS, first episode psychosis (FEP) and HC subjects. We expected a better verbal learning and memory performance of women in all groups. METHODS: The neuropsychological data analysed in this study were collected within the prospective Fruherkennung von Psychosen (FePsy) study. In total, 118 ARMS, 88 FEP individuals and 86 HC completed a cognitive test battery covering the domains of executive functions, attention, working memory, verbal learning and memory, IQ and speed of processing. RESULTS: Women performed better in verbal learning and memory regardless of diagnostic group. By contrast, men as compared to women showed a shorter reaction time during the working memory task across all groups. CONCLUSION: The results provide evidence that women generally perform better in verbal learning and memory, independent of diagnostic group (ARMS, FEP, HC). The finding of a shorter reaction time for men in the working memory task could indicate that men have a superior working memory performance since they responded faster during the target trials, while maintaining a comparable overall working memory performance level.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
UniBasel Contributors:Riecher-Rössler, Anita and Studerus, Erich
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0924-9338
e-ISSN:1778-3585
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:07 Jun 2019 08:28
Deposited On:02 Apr 2019 13:44

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