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Recognition molecule associated carbohydrate inhibits postsynaptic GABA(B) receptors : a mechanism for homeostatic regulation of GABA release in perisomatic synapses

Saghatelyan, Armen K. and Snapyan, Marina and Gorissen, Silke and Meigel, Inge and Mosbacher, Johannes and Kaupmann, Klemens and Bettler, Bernhard and Kornilov, Andrei V. and Nifantiev, Nikolay E. and Sakanyan, Vehary and Schachner, Melitta and Dityatev, Alexander. (2003) Recognition molecule associated carbohydrate inhibits postsynaptic GABA(B) receptors : a mechanism for homeostatic regulation of GABA release in perisomatic synapses. Molecular and cellular neuroscience, Vol. 24, H. 2. pp. 271-282.

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Official URL: http://edoc.unibas.ch/dok/A5262251

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Abstract

Extracellular matrix molecules are important cues in the shaping of nervous system structure and function. Here, we describe a novel mechanism by which the HNK-1 carbohydrate carried by recognition molecules regulates perisomatic inhibition in the hippocampus. Neutralization of HNK-1 activity by an HNK-1 antibody results in GABA(B) receptor-mediated activation of K(+) currents in CA1 pyramidal cells, which elevates extracellular K(+) concentration and reduces evoked GABA release in perisomatic inhibitory synapses. This mechanism is supported by pharmacological analysis in hippocampal slices and data showing that the HNK-1 carbohydrate binds to GABA(B) receptors and inhibits GABA(B) receptor-activated K(+) currents in a heterologous expression system. We suggest that the HNK-1 carbohydrate is involved in homeostatic regulation of GABA(A) receptor-mediated perisomatic inhibition by suppression of postsynaptic GABA(B) receptor activity.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > Molecular Neurobiology Synaptic Plasticity (Bettler)
UniBasel Contributors:Bettler, Bernhard
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Academic Press
ISSN:1044-7431
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:36

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