Altered peripheral myelination in mice lacking GABAB receptors

Magnaghi, Valerio and Ballabio, Marinella and Camozzi, Francesca and Colleoni, Mariapia and Consoli, Antonio and Gassmann, Martin and Lauria, Giuseppe and Motta, Marcella and Procacci, Patrizia and Trovato, Anna Elisa and Bettler, Bernhard. (2008) Altered peripheral myelination in mice lacking GABAB receptors. Molecular and cellular neuroscience, Vol. 37, H. 3. pp. 599-609.

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Official URL: http://edoc.unibas.ch/dok/A5262214

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Emerging evidence implicates gamma-aminobutyric acid type B (GABA(B)) receptors in peripheral nervous system (PNS) functions. In order to elucidate which biochemical, morphological and functional parameters of peripheral nerve fibers depend on GABA(B) receptors we studied GABA(B1)-deficient mice, which are devoid of functional GABA(B) receptors. Here, we show that GABA(B1)-deficient mice exhibit morphological and molecular changes in peripheral myelin, including an increase in the number of irregular fibers and increases in the expression levels of the myelin proteins PMP22 and P0. Moreover, the number of small myelinated fibers and small neurons of the lumbar dorsal root ganglia is higher in GABA(B1)-deficient mice than in wild-type littermates. We further show that GABA(B1)-deficient mice exhibit gait alterations and reduced allodynia. In summary, our findings implicate GABA(B) receptors in the PNS myelination process and raise the possibility that PNS alterations contribute to the sensory phenotypes of GABA(B1)-deficient mice.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > Molecular Neurobiology Synaptic Plasticity (Bettler)
UniBasel Contributors:Bettler, Bernhard
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Academic Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Oct 2012 15:30
Deposited On:22 Mar 2012 13:36

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