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Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Nagel, Gabriele and Stafoggia, Massimo and Pedersen, Marie and Andersen, Zorana J. and Galassi, Claudia and Munkenast, Jule and Jaensch, Andrea and Sommar, Johan and Forsberg, Bertil and Olsson, David and Oftedal, Bente and Krog, Norun H. and Aamodt, Geir and Pyko, Andrei and Pershagen, Göran and Korek, Michal and De Faire, Ulf and Pedersen, Nancy L. and Östenson, Claes-Göran and Fratiglioni, Laura and Sørensen, Mette and Tjønneland, Anne and Peeters, Petra H. and Bueno-de-Mesquita, Bas and Vermeulen, Roel and Eeftens, Marloes and Plusquin, Michelle and Key, Timothy J. and Concin, Hans and Lang, Alois and Wang, Meng and Tsai, Ming-Yi and Grioni, Sara and Marcon, Alessandro and Krogh, Vittorio and Ricceri, Fulvio and Sacerdote, Carlotta and Ranzi, Andrea and Cesaroni, Giulia and Forastiere, Francesco and Tamayo-Uria, Ibon and Amiano, Pilar and Dorronsoro, Miren and de Hoogh, Kees and Beelen, Rob and Vineis, Paolo and Brunekreef, Bert and Hoek, Gerard and Raaschou-Nielsen, Ole and Weinmayr, Gudrun. (2018) Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE). International journal of cancer, 143 (7). pp. 1632-1643.

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Abstract

Air pollution has been classified as carcinogenic to humans. However, to date little is known about the relevance for cancers of the stomach and upper aerodigestive tract (UADT). We investigated the association of long-term exposure to ambient air pollution with incidence of gastric and UADT cancer in 11 European cohorts. Air pollution exposure was assigned by land-use regression models for particulate matter (PM) below 10 µm (PM; 10; ), below 2.5 µm (PM; 2.5; ), between 2.5 and 10 µm (PM; coarse; ), PM; 2.5; absorbance and nitrogen oxides (NO; 2; and NO; X; ) as well as approximated by traffic indicators. Cox regression models with adjustment for potential confounders were used for cohort-specific analyses. Combined estimates were determined with random effects meta-analyses. During average follow-up of 14.1 years of 305,551 individuals, 744 incident cases of gastric cancer and 933 of UADT cancer occurred. The hazard ratio for an increase of 5 µg/m; 3; of PM; 2.5; was 1.38 (95% CI 0.99; 1.92) for gastric and 1.05 (95% CI 0.62; 1.77) for UADT cancers. No associations were found for any of the other exposures considered. Adjustment for additional confounders and restriction to study participants with stable addresses did not influence markedly the effect estimate for PM; 2.5; and gastric cancer. Higher estimated risks of gastric cancer associated with PM; 2.5; was found in men (HR 1.98 [1.30; 3.01]) as compared to women (HR 0.85 [0.5; 1.45]). This large multicentre cohort study shows an association between long-term exposure to PM; 2.5; and gastric cancer, but not UADT cancers, suggesting that air pollution may contribute to gastric cancer risk.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:Eeftens, Marloes and Tsai, Ming-Yi and de Hoogh, Kees
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Alan R. Liss
ISSN:0020-7136
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:05 Jun 2019 14:32
Deposited On:31 Jan 2019 13:13

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