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Disruption of CREB function in brain leads to neurodegeneration

Mantamadiotis, Theo and Lemberger, Thomas and Bleckmann, Susanne C. and Kern, Heidrun and Kretz, Oliver and Martin Villalba, Ana and Tronche, François and Kellendonk, Christoph and Gau, Daniel and Kapfhammer, Josef and Otto, Christiane and Schmid, Wolfgang and Schütz, Günther. (2002) Disruption of CREB function in brain leads to neurodegeneration. Nature genetics, Vol. 31, H. 1. pp. 47-54.

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Official URL: http://edoc.unibas.ch/dok/A5262196

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Abstract

Control of cellular survival and proliferation is dependent on extracellular signals and is a prerequisite for ordered tissue development and maintenance. Activation of the cAMP responsive element binding protein (CREB) by phosphorylation has been implicated in the survival of mammalian cells. To define its roles in the mouse central nervous system, we disrupted Creb1 in brain of developing and adult mice using the Cre/loxP system. Mice with a Crem(-/-) background and lacking Creb in the central nervous system during development show extensive apoptosis of postmitotic neurons. By contrast, mice in which both Creb1 and Crem are disrupted in the postnatal forebrain show progressive neurodegeneration in the hippocampus and in the dorsolateral striatum. The striatal phenotype is reminiscent of Huntington disease and is consistent with the postulated role of CREB-mediated signaling in polyglutamine-triggered diseases.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Anatomy > Developmental Neurobiology and Regeneration (Kapfhammer)
UniBasel Contributors:Kapfhammer, Josef
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publ
ISSN:1061-4036
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:36

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