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Expression of RET is associated with Oestrogen receptor expression but lacks prognostic significance in breast cancer

Mechera, Robert and Soysal, Savas D. and Piscuoglio, Salvatore and Ng, Charlotte K. Y. and Zeindler, Jasmin and Mujagic, Edin and Däster, Silvio and Glauser, Philippe and Hoffmann, Henry and Kilic, Ergin and Droeser, Raoul A. and Weber, Walter P. and Muenst, Simone. (2019) Expression of RET is associated with Oestrogen receptor expression but lacks prognostic significance in breast cancer. BMC cancer, 19 (1). p. 41.

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Abstract

The Rearranged during Transfection (RET) protein is overexpressed in a subset of Estrogen Receptor (ER) positive breast cancer, with both signalling pathways functionally interacting. This cross-talk plays a pivotal role in the resistance of breast cancer cells to anti-endocrine therapies, and RET expression is assumed to correlate with poor prognosis based on findings in small patient cohorts. The aim of our study was to investigate the impact of RET expression on patient outcome in human breast cancer.; We performed an immunohistochemical analysis of RET protein expression on a tissue microarray encompassing 990 breast cancer patients and correlated its expression with clinicopathological parameters and survival data.; Expression of RET was detected in 409 out of 990 cases (41.3%). RET and ER expression significantly correlated (p < 0.0001). The Luminal B HER2-positive subtype showed the highest expression rate (48.9%). In univariate and multivariate survival analyses, RET expression had no impact on overall survival.; We confirmed the co-expression of RET and ER, but we did not find RET expression to be an independent prognostic factor in human breast cancer. Clinical trials with newly developed RET inhibitors are needed to evaluate if RET inhibition has a beneficial impact on patient survival in ER positive breast cancer.
Faculties and Departments:03 Faculty of Medicine
03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB
UniBasel Contributors:Piscuoglio, Salvatore
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:BMC
ISSN:1471-2407
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:29 Jan 2019 10:13
Deposited On:29 Jan 2019 10:13

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