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Sensitivity of the point-of-care circulating cathodic antigen urine cassette test for diagnosis of Schistosoma mansoni in low-endemicity settings in Côte d'Ivoire

Assaré, Rufin K. and Tra, Mathieu B. I. and Ouattara, Mamadou and Hürlimann, Eveline and Coulibaly, Jean T. and N'Goran, Eliézer K. and Utzinger, Jürg. (2018) Sensitivity of the point-of-care circulating cathodic antigen urine cassette test for diagnosis of Schistosoma mansoni in low-endemicity settings in Côte d'Ivoire. American journal of tropical medicine and hygiene, 99 (6). pp. 1567-1572.

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Official URL: https://edoc.unibas.ch/67906/

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Abstract

The sensitivity of a point-of-care circulating cathodic antigen (POC-CCA) urine cassette test for diagnosis of; Schistosoma mansoni; in low-endemicity settings is poorly understood. We conducted a cross-sectional survey in 14 villages in western Côte d'Ivoire and diagnosed children aged 9-12 years for schistosomiasis. Two stool samples were subjected to triplicate Kato-Katz thick smears each for diagnosis of; S. mansoni; , whereas a single urine sample was examined by POC-CCA for; S. mansoni,; filtration for; Schistosoma haematobium,; and reagent strip for microhematuria. According to the Kato-Katz technique, we found 45 out of 681 children positive for; S. mansoni; (6.6%) with a mean intensity among infected children of 72.2 eggs per gram of stool. Point-of-care circulating cathodic antigen revealed a prevalence of; S. mansoni; of 33.0% when trace results were considered positive and 12.5% when trace results were considered negative. Eggs of; S. haematobium; were found in eight participants (1.2%), whereas the prevalence of microhematuria was 13.5%. A single POC-CCA urine cassette test revealed a several-fold higher prevalence of; S. mansoni; than multiple Kato-Katz thick smears in this low-endemicity area. Our findings have important ramifications for choosing an appropriate diagnostic tool in low-endemic areas that might be targeted for elimination.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Eco System Health Sciences > Health Impact Assessment (Utzinger)
UniBasel Contributors:Hürlimann, Eveline and Coulibaly, Jean and Utzinger, Jürg
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Williams and Wilkins
ISSN:0002-9637
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:15 Jan 2019 13:50
Deposited On:15 Jan 2019 13:50

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