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Cingulate volume abnormalities in emerging psychosis

Röthlisberger, Michel and Riecher-Rössler, Anita and Aston, Jacqueline and Fusar-Poli, Paolo and Radü, Ernst-Wilhelm and Borgwardt, Stefan. (2012) Cingulate volume abnormalities in emerging psychosis. Current Pharmaceutical Design, 18 (4). pp. 495-504.

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Official URL: https://edoc.unibas.ch/67862/

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Abstract

Background: Neuroanatomical abnormalities, including cingulate cortex volume abnormalities, are a common feature in psychosis. However, the extent to which these are related to a vulnerability to psychosis, as opposed to the disorder per se, is less certain. Aim und Hypotheses: The aim of the present study is to compare cingulate gray matter volumes in different stages of psychosis. We reviewed previous studies of subjects in a prodromal stage of psychosis and tested of cingulate volume changes during the transition to psychosis. Methods: A cross-sectional MRI study of manually traced cingulate gray-matter volumes in 37 individuals with an At Risk Mental State (ARMS) for psychosis, 23 individuals with First-Episode Psychosis (FEP), and 22 Healthy Controls (HC) was performed using a 1.5T MRI-Scanner. 16 of 37 ARMS individuals (43 %) developed psychosis during follow up (ARMS-T), whereas 21 did not (ARMS-NT). The mean duration of follow up in ARMS was 25.1 months. 8 cingulate subregionswere analysedin a region-of-interest analysis. Results: Compared to HC, subjects with an ARMS had significantly reduced left caudal anterior cingulate cortex volume (p<0.027). This finding was also evident at a trend level (p: 0.069) in FEP patients. Within the ARMS, ARMS-T group showed significantly reduced whole right cingulate cortex (p: 0.036), right subgenual cingulate cortex (p: 0.036) and right posterior cingulate cortex (p: 0.012) compared to ARMS-NT. Discussion: These results suggest that theat-risk mental state is associated with cingulate volume reductions in particular in the left caudal anterior cingulate cortex (CACC). These abnormalities do not only seem to occur with transition to psychosis, but may be a correlate of an increased vulnerability to psychosis.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
UniBasel Contributors:Riecher-Rössler, Anita
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Bentham Science Pulisher
ISSN:1381-6128
e-ISSN:1873-4286
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:24 Sep 2019 16:02
Deposited On:09 Jan 2019 15:25

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