Differences between Unipolar Mania and Bipolar-I Disorder: Evidence from Nine Epidemiological Studies

Angst, Jules and Rössler, Wulf and Ajdacic-Gross, Vladeta and Angst, Felix and Wittchen, Hans Ulrich and Lieb, Roselind and Beesdo-Baum, Katja and Asselmann, Eva and Merikangas, Kathleen R. and Cui, Lihong and Andrade, Laura H. and Viana, Maria C. and Lamers, Femke and Penninx, Brenda Wjh and de Azevedo Cardoso, Taiane and Jansen, Karen and Dias de Mattos Souza, Luciano and Azevedo da Silva, Ricardo and Kapczinski, Flavio and Grobler, Christoffel and Gholam-Rezaee, Mehdi and Preisig, Martin and Vandeleur, Caroline L.. (2018) Differences between Unipolar Mania and Bipolar-I Disorder: Evidence from Nine Epidemiological Studies. Bipolar disorders. pp. 1-12.

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Official URL: https://edoc.unibas.ch/67418/

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Although clinical evidence suggests important differences between unipolar mania and bipolar-I disorder (BP-I), epidemiological data are limited. Combining data from nine population-based studies, we compared subjects with mania (M) or mania with mild depression (Md) to those with BP-I with both manic and depressive episodes with respect to demographic and clinical characteristics in order to highlight differences.; Participants were compared for gender, age, age at onset of mania, psychiatric comorbidity, temperament, and family history of mental disorders. Generalized linear mixed models with adjustment for sex and age as well as for each study source were applied. Analyses were performed for the pooled adult and adolescent samples, separately.; Within the included cohorts, 109 adults and 195 adolescents were diagnosed with M/Md and 323 adults and 182 adolescents with BP-I. In both adult and adolescent samples, there was a male preponderance in M/Md, whereas lifetime generalized anxiety and/panic disorders and suicide attempts were less common in M/Md than in BP-I. Furthermore, adults with mania revealed bulimia/binge eating and drug use disorders less frequently than those with BP-I.; The significant differences found in gender and comorbidity between mania and BP-I suggest that unipolar mania, despite its low prevalence, should be established as a separate diagnosis both for clinical and research purposes. In clinical settings, the rarer occurrence of suicide attempts, anxiety, and drug use disorders among individuals with unipolar mania may facilitate successful treatment of the disorder and lead to a more favorable course than that of BP-I disorder.
Faculties and Departments:07 Faculty of Psychology
UniBasel Contributors:Lieb, Roselind
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Apr 2020 12:07
Deposited On:20 Dec 2018 12:58

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