edoc

Open-label placebo response - Does optimism matter? A secondary-analysis of a randomized controlled trial

Locher, Cosima and Frey Nascimento, Antje and Kossowsky, Joe and Meyer, Andrea and Gaab, Jens. (2019) Open-label placebo response - Does optimism matter? A secondary-analysis of a randomized controlled trial. Journal of psychosomatic research, 116. pp. 25-30.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/67286/

Downloads: Statistics Overview

Abstract

Objective Open-label placebos (OLPs) have been found to elicit significant and clinical meaningful effects, but in comparison to deceptive placebo administration there is a lack of research regarding possible predictors. This study sets out to examine the effects of optimism and other personality-related variables on OLP responses. Methods We conducted a secondary-analysis of an OLP trial in healthy participants ( N = 160), who were randomized to no treatment (NT), OLP without rationale (OPR − ), OLP with rationale (OPR + ), and deceptive placebo (DP) in an experimental heat pain paradigm. Results The association between objective posttreatment pain tolerance and optimism did not differ among groups. However, for subjective heat pain ratings at posttreatment, regression analyses showed a significant interaction between group and optimism scores in subjective intensity (F[3, 142] = 3.81, P = 0.012) and unpleasantness ratings (F[3, 142] = 2.95, P = 0.035), indicating that the association between optimism and subjective ratings differed among groups, in particular between OPR + and NT (intensity: P = 0.012; unpleasantness: P = 0.037), and OPR + and DP (intensity: P = 0.016). Thus, higher optimism scores were negatively associated with subjective ratings in the NT and DP groups but not in the OPR + group. Additional exploratory analyses revealed no significant interactions between group and further personality-related variables on heat pain analgesia . Conclusion Taken together, OLPs are effective, the underlying personality-related variables seem, however, to differ significantly from the deceptive placebo response. Therefore, the concept of "placebo responders" might depend on the route of placebo administration.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Psychotherapie (Gaab)
UniBasel Contributors:Frey Nascimento, Antje and Kossowsky, Joe and Gaab, Jens and Locher, Cosima
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Pergamon Press
ISSN:0022-3999
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:22 May 2019 13:18
Deposited On:22 May 2019 13:18

Repository Staff Only: item control page