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The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa

Park, Se Eun and Pham, Duy Thanh and Boinett, Christine and Wong, Vanessa K. and Pak, Gi Deok and Panzner, Ursula and Espinoza, Ligia Maria Cruz and von Kalckreuth, Vera and Im, Justin and Schütt-Gerowitt, Heidi and Crump, John A. and Breiman, Robert F. and Adu-Sarkodie, Yaw and Owusu-Dabo, Ellis and Rakotozandrindrainy, Raphaël and Soura, Abdramane Bassiahi and Aseffa, Abraham and Gasmelseed, Nagla and Keddy, Karen H. and May, Jürgen and Sow, Amy Gassama and Aaby, Peter and Biggs, Holly M. and Hertz, Julian T. and Montgomery, Joel M. and Cosmas, Leonard and Olack, Beatrice and Fields, Barry and Sarpong, Nimako and Razafindrabe, Tsiriniaina Jean Luco and Raminosoa, Tiana Mirana and Kabore, Leon Parfait and Sampo, Emmanuel and Teferi, Mekonnen and Yeshitela, Biruk and El Tayeb, Muna Ahmed and Sooka, Arvinda and Meyer, Christian G. and Krumkamp, Ralf and Dekker, Denise Myriam and Jaeger, Anna and Poppert, Sven and Tall, Adama and Niang, Aissatou and Bjerregaard-Andersen, Morten and Løfberg, Sandra Valborg and Seo, Hye Jin and Jeon, Hyon Jin and Deerin, Jessica Fung and Park, Jinkyung and Konings, Frank and Ali, Mohammad and Clemens, John D. and Hughes, Peter and Sendagala, Juliet Nsimire and Vudriko, Tobias and Downing, Robert and Ikumapayi, Usman N. and Mackenzie, Grant A. and Obaro, Stephen and Argimon, Silvia and Aanensen, David M. and Page, Andrew and Keane, Jacqueline A. and Duchene, Sebastian and Dyson, Zoe and Holt, Kathryn E. and Dougan, Gordon and Marks, Florian and Baker, Stephen. (2018) The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa. Nature Communications, 9 (1). p. 5094.

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Abstract

There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 sub-Saharan African countries, in context of the 2,057 global S. Typhi genomic framework. Despite the broad genetic diversity, the majority of organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), and 2.3.2 (29/249; 12%). Genotypes 4.3.1 and 3.1.1 are confined within East and West Africa, respectively. MDR phenotype is found in over 50% of organisms restricted within these dominant genotypes. High incidences of MDR S. Typhi are calculated in locations with a high burden of typhoid, specifically in children aged <15 years. Antimicrobial stewardship, MDR surveillance, and the introduction of typhoid conjugate vaccines will be critical for the control of MDR typhoid in Africa.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED)
UniBasel Contributors:Poppert, Sven
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
e-ISSN:2041-1723
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:17 Dec 2018 10:33
Deposited On:17 Dec 2018 10:33

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