Free intracellular calcium in peripheral cells in Alzheimer's disease

Eckert, A. and Förstl, H. and Zerfass, R. and Hennerici, M. and Müller, W. E.. (1997) Free intracellular calcium in peripheral cells in Alzheimer's disease. Neurobiology of aging, Vol. 18, H. 3. pp. 281-284.

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Official URL: http://edoc.unibas.ch/dok/A5253507

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The goal of the present study was to evaluate several parameters of free intracellular Ca2+ regulation ([Ca2+]i) in Alzheimer's disease (AD) in a very large group of patients (n = 50) and nondemented controls (n = 41), using blood lymphocytes and neutrophils as two different peripheral model systems. We found no major difference, because neither the basal [Ca2+]i, nor the activation-induced Ca2+ responses differed among neutrophils or lymphocytes from aged controls and AD patients. However, we observed a delayed Ca2+ response of AD lymphocytes after phytohemagglutinin (PHA) stimulation, indicating an impaired function of Ca2+ influx-controlling mechanisms, because Ca2+ release from intracellular stores appears to be unchanged. Because the PHA-induced Ca2+ response in lymphocytes is accelerated by beta-amyloid (Beta A) similarly to its effects on central neurons, we also investigated the effect of beta A on Ca2+ signalling with regard to AD-related alterations. In contrast to lymphocytes from aged controls, the amplifying effect on Ca2+ signalling was significantly reduced in lymphocytes from a high percentage of AD patients. The results are discussed with respect to their diagnostic potential and to a possible involvement of altered beta A sensitivity of lymphocytes in the pathophysiology of AD.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
UniBasel Contributors:Eckert, Anne
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:35

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