Systematic review of indoor residual spray efficacy and effectiveness against Plasmodium falciparum in Africa

Sherrard-Smith, Ellie and Griffin, Jamie T. and Winskill, Peter and Corbel, Vincent and Pennetier, Cédric and Djénontin, Armel and Moore, Sarah and Richardson, Jason H. and Müller, Pie and Edi, Constant and Protopopoff, Natacha and Oxborough, Richard and Agossa, Fiacre and N'Guessan, Raphael and Rowland, Mark and Churcher, Thomas S.. (2018) Systematic review of indoor residual spray efficacy and effectiveness against Plasmodium falciparum in Africa. Nature Communications, 9 (1). p. 4982.

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Official URL: https://edoc.unibas.ch/67081/

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Indoor residual spraying (IRS) is an important part of malaria control. There is a growing list of insecticide classes; pyrethroids remain the principal insecticide used in bednets but recently, novel non-pyrethroid IRS products, with contrasting impacts, have been introduced. There is an urgent need to better assess product efficacy to help decision makers choose effective and relevant tools for mosquito control. Here we use experimental hut trial data to characterise the entomological efficacy of widely-used, novel IRS insecticides. We quantify their impact against pyrethroid-resistant mosquitoes and use a Plasmodium falciparum transmission model to predict the public health impact of different IRS insecticides. We report that long-lasting IRS formulations substantially reduce malaria, though their benefit over cheaper, shorter-lived formulations depends on local factors including bednet use, seasonality, endemicity and pyrethroid resistance status of local mosquito populations. We provide a framework to help decision makers evaluate IRS product effectiveness.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Vector Biology > Vector Research and Control (Müller)
UniBasel Contributors:Moore, Sarah Jane and Müller, Pie
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Springer nature
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:11 Dec 2018 10:59
Deposited On:11 Dec 2018 10:59

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