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The Role of Norepinephrine and [alpha] -Adrenergic Receptors in Acute Stress-Induced Changes in Granulocytes and Monocytes

Beis, Daniel and von Kanel, Roland and Heimgartner, Nadja and Zuccarella-Hackl, Claudia and Buerkle, Alexander and Ehlert, Ulrike and Wirtz, Petra H.. (2018) The Role of Norepinephrine and [alpha] -Adrenergic Receptors in Acute Stress-Induced Changes in Granulocytes and Monocytes. Psychosomatic Medicine, 80 (7). pp. 649-658.

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Official URL: https://edoc.unibas.ch/66982/

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Abstract

Objective Acute stress induces redistribution of circulating leucocytes in humans. Although effects on lymphocytes as adaptive immune cells are well understood, the mechanisms underlying stress effects on granulocytes and monocytes as innate immune blood cells are still elusive. We investigated whether the stress hormone norepinephrine (NE) and -adrenergic receptors (-ADRs) may play a mediating role.Methods In a stress study, we cross-sectionally tested 44 healthy men for associations between stress-induced NE increases and simultaneous granulocyte and monocyte cell count increases, as measured immediately before and several times after the Trier Social Stress Test. In a subsequent infusion study, 21 healthy men participated in three different experimental trials with sequential infusions of 1- and 15-minute duration with varying substances (saline as placebo, the nonspecific -ADR blocker phentolamine [2.5 mg/min], and NE [5 g/min]): trial 1 = saline+saline, trial 2 = saline+NE, trial 3 = phentolamine+NE. Granulocyte and monocyte cell numbers were assessed before, immediately after, 10 minutes, and 30 minutes after infusion procedures.Results In the stress study, higher NE related to higher neutrophil stress changes ( = .31, p = .045, R-2 change = .09), but not epinephrine stress changes. In the infusion study, saline+NE induced significant increases in neutrophil (F(3/60) = 43.50, p < .001, (2) = .69) and monocyte (F(3/60) = 18.56, p < .001, (2) = .48) numbers compared with saline+saline. With phentolamine+NE, neutrophil (F(3/60) = 14.41, p < .001, (2) = .42) and monocyte counts (F(2.23/44.6) = 4.32, p = .016, (2) = .18) remained increased compared with saline+saline but were lower compared with saline+NE (neutrophils: F(3/60) = 19.55, p < .001, (2) = .494, monocytes: F(3/60) = 2.54, p = .065, (2) = .11) indicating partial mediation by -ADRs. Trials did not differ in eosinophil and basophil count reactivity.Conclusions Our findings suggest that NE-induced immediate increases in neutrophil and monocyte numbers resemble psychosocial stress effects and can be reduced by blockade of -ADRs.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Abteilung Clinical Child and Adolescent Psychology
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Psychotherapie (Gaab)
UniBasel Contributors:Heimgartner, Nadja
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott Williams & Wilkins
ISSN:0033-3174
e-ISSN:1534-7796
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Nov 2018 15:50
Deposited On:29 Nov 2018 15:50

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