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Modeling of Protein Tertiary and Quaternary Structures Based on Evolutionary Information

Studer, Gabriel and Tauriello, Gerardo and Bienert, Stefan and Waterhouse, Andrew Mark and Bertoni, Martino and Bordoli, Lorenza and Schwede, Torsten and Lepore, Rosalba. (2019) Modeling of Protein Tertiary and Quaternary Structures Based on Evolutionary Information. Methods in Molecular Biology, 1851. pp. 301-316.

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Official URL: https://edoc.unibas.ch/66710/

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Abstract

Proteins are subject to evolutionary forces that shape their three-dimensional structure to meet specific functional demands. The knowledge of the structure of a protein is therefore instrumental to gain information about the molecular basis of its function. However, experimental structure determination is inherently time consuming and expensive, making it impossible to follow the explosion of sequence data deriving from genome-scale projects. As a consequence, computational structural modeling techniques have received much attention and established themselves as a valuable complement to experimental structural biology efforts. Among these, comparative modeling remains the method of choice to model the three-dimensional structure of a protein when homology to a protein of known structure can be detected.The general strategy consists of using experimentally determined structures of proteins as templates for the generation of three-dimensional models of related family members (targets) of which the structure is unknown. This chapter provides a description of the individual steps needed to obtain a comparative model using SWISS-MODEL, one of the most widely used automated servers for protein structure homology modeling.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Schwede)
10 Zentrale universitäre Einrichtungen > SciCore
UniBasel Contributors:Studer, Gabriel and Tauriello, Gerardo and Bienert, Stefan and Waterhouse, Andrew Mark and Bertoni, Martino and Bordoli, Lorenza and Schwede, Torsten and Lepore, Rosalba
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Humana Press
ISSN:1064-3745
e-ISSN:1940-6029
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:23 May 2019 13:51
Deposited On:23 May 2019 13:51

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