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Occupational exposures and 20-year incidence of COPD : the European Community Respiratory Health Survey

Lytras, Theodore and Kogevinas, Manolis and Kromhout, Hans and Carsin, Anne-Elie and Antó, Josep M. and Bentouhami, Hayat and Weyler, Joost and Heinrich, Joachim and Nowak, Dennis and Urrutia, Isabel and Martinez-Moratalla, Jesús and Gullón, José Antonio and Pereira-Vega, Antonio and Raherison-Semjen, Chantal and Pin, Isabelle and Demoly, Pascal and Leynaert, Bénédicte and Villani, Simona and Gislason, Thorarinn and Svanes, Cecilie and Holm, Mathias and Forsberg, Bertil and Norbäck, Dan and Mehta, Amar J. and Probst-Hensch, Nicole and Benke, Geza and Jogi, Rain and Torén, Kjell and Sigsgaard, Torben and Schlünssen, Vivi and Olivieri, Mario and Blanc, Paul D. and Vermeulen, Roel and Garcia-Aymerich, Judith and Jarvis, Deborah and Zock, Jan-Paul. (2018) Occupational exposures and 20-year incidence of COPD : the European Community Respiratory Health Survey. Thorax, 73 (11). pp. 1008-1015.

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Official URL: https://edoc.unibas.ch/66700/

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Abstract

Occupational exposures have been associated with an increased risk of COPD. However, few studies have related objectively assessed occupational exposures to prospectively assessed incidence of COPD, using postbronchodilator lung function tests. Our objective was to examine the effect of occupational exposures on COPD incidence in the European Community Respiratory Health Survey.; General population samples aged 20-44 were randomly selected in 1991-1993 and followed up 20 years later (2010-2012). Spirometry was performed at baseline and at follow-up, with incident COPD defined using a lower limit of normal criterion for postbronchodilator FEV1/FVC. Only participants without COPD and without current asthma at baseline were included. Coded job histories during follow-up were linked to a Job-Exposure Matrix, generating occupational exposure estimates to 12 categories of agents. Their association with COPD incidence was examined in log-binomial models fitted in a Bayesian framework.; 3343 participants fulfilled the inclusion criteria; 89 of them had COPD at follow-up (1.4 cases/1000 person-years). Participants exposed to biological dust had a higher incidence of COPD compared with those unexposed (relative risk (RR) 1.6, 95% CI 1.1 to 2.3), as did those exposed to gases and fumes (RR 1.5, 95% CI 1.0 to 2.2) and pesticides (RR 2.2, 95% CI 1.1 to 3.8). The combined population attributable fraction for these exposures was 21.0%.; These results substantially strengthen the evidence base for occupational exposures as an important risk factor for COPD.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Probst Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:British Medical Association
ISSN:0040-6376
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Nov 2018 13:00
Deposited On:22 Nov 2018 13:00

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