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Effects of vancomycin and ciprofloxacin on the NMRI mouse metabolism

Liu, Zhigang and Xia, Bing and Saric, Jasmina and Utzinger, Jürg and Holmes, Elaine and Keiser, Jennifer and Li, Jia V.. (2018) Effects of vancomycin and ciprofloxacin on the NMRI mouse metabolism. Journal of Proteome Research, 17 (10). pp. 3565-3573.

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Official URL: https://edoc.unibas.ch/66682/

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Abstract

The reduction in gut microbiota diversity is associated with a range of human diseases. Overuse of antibiotics has been associated with a diminished gut-microbial diversity in humans and may promote microbiota-associated negative effects to physical health, such as the metabolic syndrome-cluster of diseases and mental illnesses. There is a pressing need to deepen the understanding of the effects of antibiotics at the biochemical level. The current study investigated metabolic effects of two widely prescribed antibiotics-vancomycin and ciprofloxacin-on biofluids and brain tissue samples of NMRI female mice using a; 1; H nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling approach. While both antibiotics significantly affected the host metabolic signatures of urine and feces, only ciprofloxacin induced metabolic changes in plasma. Metabolic perturbations were pronounced 1 day post-treatment, reverting back to baseline at day 20 post-treatment. Both antibiotics induced changes in the choline metabolism, host-microbial cometabolites, short chain fatty acid production, and protein/purine degradation. The metabolic profiles of brain tissue aqueous extracts did not show any antibiotics-related changes by day 20 post-treatment. The data suggest that the metabolic disruptions in biofluids caused by antibiotics are reversed by day 20 post-treatment when compared to the pre-treatment profiles.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Eco System Health Sciences > Health Impact Assessment (Utzinger)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Helminth Drug Development (Keiser)
UniBasel Contributors:Utzinger, Jürg and Keiser, Jennifer and Saric, Jasmina
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:1535-3893
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:15 Nov 2018 15:32
Deposited On:15 Nov 2018 15:32

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