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Connecting Circuits for Supraspinal Control of Locomotion

Ferreira-Pinto, Manuel J. and Ruder, Ludwig and Capelli, Paolo and Arber, Silvia. (2018) Connecting Circuits for Supraspinal Control of Locomotion. Neuron, 100 (2). pp. 361-374.

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Official URL: https://edoc.unibas.ch/66579/

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Abstract

Locomotion is regulated by distributed circuits and achieved by the concerted activation of body musculature. While the basic properties of executive circuits in the spinal cord are fairly well understood, the precise mechanisms by which the brain impacts locomotion are much less clear. This Review discusses recent work unraveling the cellular identity, connectivity, and function of supraspinal circuits. We focus on their involvement in the regulation of the different phases of locomotion and their interaction with spinal circuits. Dedicated neuronal populations in the brainstem carry locomotor instructions, including initiation, speed, and termination. To align locomotion with behavioral needs, brainstem output structures are recruited by midbrain and forebrain circuits that compute and infer volitional, innate, and context-dependent locomotor properties. We conclude that the emerging logic of supraspinal circuit organization helps to understand how locomotor programs from exploration to hunting and escape are regulated by the brain.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)
09 Associated Institutions > Friedrich Miescher Institut FMI
UniBasel Contributors:Arber, Silvia and Neves Ferreira Pinto, Manuel and Ruder, Ludwig and Capelli, Paolo
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1097-4199
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:09 Oct 2019 13:50
Deposited On:09 Oct 2019 13:50

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