Leydig cell injury as a consequence of an acute graft-versus-host reaction

Wagner, Anna-Margaretha and Beier, Konstantin and Christen, Elli and Holländer, Georg A. and Krenger, Werner. (2005) Leydig cell injury as a consequence of an acute graft-versus-host reaction. Blood, Vol. 105, H. 7. pp. 2988-2890.

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Official URL: http://edoc.unibas.ch/dok/A5251951

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Hematopoietic stem cell transplantation (HSCT) is associated with significant posttransplantation gonadotoxicity. This deficit has been mainly attributed to pretransplantation conditioning, but lower sperm counts in humans also appear to be associated with graft-versus-host disease (GVHD) following allogeneic HSCT. However, the mechanisms leading to diminished spermatocyte levels during GVHD remain unknown. Here we demonstrate that injury to intratesticular cells occurs in unconditioned F1 mice following the infiltration of donor alloreactive T cells during an acute graft-versus-host reaction (GVHR). Using computer-aided quantitative microscopic morphometry we demonstrate that the nadir of Leydig cell volume density coincides with the peak of intratesticular infiltration by donor T cells. Injury to Leydig cells correlates with an intratesticular inflammatory response characterized by interferon-gamma and tumor necrosis factor-alpha production. These results demonstrate impairment of testosterone-producing Leydig cells during a local alloresponse, thus representing a mechanism that contributes to gonadal insufficiency following allogeneic HSCT.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Anatomy > Histologie (Beier)
UniBasel Contributors:Krenger, Werner and Beier, Konstantin
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:35

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