edoc

A three-generation study on the association of tobacco smoking with asthma

Accordini, Simone and Calciano, Lucia and Johannessen, Ane and Portas, Laura and Benediktsdóttir, Bryndis and Bertelsen, Randi Jacobsen and Bråbäck, Lennart and Carsin, Anne-Elie and Dharmage, Shyamali C. and Dratva, Julia and Forsberg, Bertil and Gomez Real, Francisco and Heinrich, Joachim and Holloway, John W. and Holm, Mathias and Janson, Christer and Jögi, Rain and Leynaert, Bénédicte and Malinovschi, Andrei and Marcon, Alessandro and Martínez-Moratalla Rovira, Jesús and Raherison, Chantal and Sánchez-Ramos, José Luis and Schlünssen, Vivi and Bono, Roberto and Corsico, Angelo G. and Demoly, Pascal and Dorado Arenas, Sandra and Nowak, Dennis and Pin, Isabelle and Weyler, Joost and Jarvis, Deborah and Svanes, Cecilie and Ageing Lungs in European Cohorts Study, . (2018) A three-generation study on the association of tobacco smoking with asthma. International journal of epidemiology, 47 (4). pp. 1106-1117.

[img] PDF - Published Version
Available under License CC BY-NC (Attribution-NonCommercial).

625Kb

Official URL: https://edoc.unibas.ch/65594/

Downloads: Statistics Overview

Abstract

Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma.; Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents' (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines.; Fathers' smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01-2.01] and mothers' smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers' smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55).; Fathers' smoking during early adolescence and grandmothers' and mothers' smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.; European Union (Horizon 2020, GA-633212).
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Dratva, Julia
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Oxford University Press
ISSN:0300-5771
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:11 Oct 2018 16:04
Deposited On:11 Oct 2018 16:04

Repository Staff Only: item control page