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Motor cortex excitability after vagus nerve stimulation in major depression

Bajbouj, Malek and Gallinat, Juergen and Lang, Undine E. and Hellen, Florence and Vesper, Jan and Lisanby, Sarah H. and Danker-Hopfe, Heidi and Neu, Peter. (2007) Motor cortex excitability after vagus nerve stimulation in major depression. Journal of Clinical Psychopharmacology, 27 (2). pp. 156-159.

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Official URL: https://edoc.unibas.ch/65545/

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Abstract

Recent data suggest that inhibitory pathways may be involved in the pathophysiology of depression and in the mode of action of some antidepressant interventions. The aim of the present study was to test whether vagus nerve stimulation (VNS) can affect motor cortex excitability. Measures of motor cortical excitability were probed by using single-pulse and paired-pulse transcranial magnetic stimulation at baseline, after 10 weeks of left VNS, and additionally, in an on-off paradigm in 10 patients with treatment-resistant unipolar depression. Ten weeks of VNS was associated with a selective and pronounced increase in intracortical inhibition, whereas no changes occurred in the on-off paradigm. These results suggest that VNS is capable of changing motor cortical excitability in patients with depression.
Faculties and Departments:03 Faculty of Medicine
03 Faculty of Medicine > Bereich Psychiatrie (Klinik)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik)
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Lang)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Lang)
03 Faculty of Medicine > Departement Klinische Forschung
UniBasel Contributors:Lang, Undine
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott Williams & Wilkins
ISSN:0271-0749
e-ISSN:1533-712X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Nov 2020 16:05
Deposited On:30 Nov 2020 16:05

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