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Impact of levodopa on reduced nerve growth factor levels in patients with Parkinson disease

Müller, Thomas and Lang, Undine E. and Muhlack, Siegfried and Welnic, Jacub and Hellweg, Rainer. (2015) Impact of levodopa on reduced nerve growth factor levels in patients with Parkinson disease. Clinical neuropharmacology, 28 (5). pp. 238-240.

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Official URL: https://edoc.unibas.ch/65528/

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Abstract

The author s found 6.5-fold reduced nerve growth factor (NGF) levels in the plasma of treated patients with Parkinson disease (PD) compared with healthy control subjects (P = 0.03). A significant positive correlation between levodopa and NGF plasma levels appeared after acute levodopa/benserazide administration. The data suggest that acute levodopa administration may contribute to an increase of NGF plasma concentrations, which are reduced in treated PD patients due to the ongoing disease process itself or chronic antiparkinsonian drug treatment.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Lang)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Lang)
UniBasel Contributors:Lang, Undine
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott Williams & Wilkins
ISSN:0362-5664
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:30 Nov 2020 15:57
Deposited On:30 Nov 2020 15:57

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