The role of preoperative blood parameters to predict the risk of surgical site infection

Mujagic, Edin and Marti, Walter R. and Coslovsky, Michael and Zeindler, Jasmin and Staubli, Sebastian and Marti, Regula and Mechera, Robert and Soysal, Savas D. and Gürke, Lorenz and Weber, Walter P.. (2018) The role of preoperative blood parameters to predict the risk of surgical site infection. American Journal of Surgery, 215 (4). pp. 651-657.

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Routine preoperative blood work is not recommended but selected biochemical markers may predict the risk of surgical site infection (SSI). This study examines the association between preoperative biochemical markers and the risk of SSI.; This observational cohort study, nested in a randomized controlled trial, was conducted at two tertiary referral centers in Switzerland.; 122 (5.8%) of 2093 patients experienced SSI. Preoperative increasing levels of albumin (OR 0.93), CRP (OR 1.34), hemoglobin (OR 0.87) and eGFR (OR 0.90) were significantly associated with the odds of SSI. The same accounts for categorized parameters. The highest area under the curve from ROC curves was 0.62 for albumin. Positive predictive values ranged from 6.4% to 9.5% and negative predictive values from 94.8% to 95.7%. The association of CRP, mildly and moderately decreased eGFR and hemoglobin with the odds of SSI remained significant on multivariate analysis.; Our results do not support generally delaying elective surgery based on preoperative blood results. However, it may be considered in situations with potentially severe sequelae of SSI.
Faculties and Departments:03 Faculty of Medicine
03 Faculty of Medicine > Bereich Operative Fächer (Klinik)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik)
UniBasel Contributors:Zeindler, Jasmin
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:05 Oct 2018 14:27
Deposited On:05 Oct 2018 14:27

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