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Delivery of ROS Generating Anthraquinones Using Reduction-Responsive Peptide-Based Nanoparticles

Richard, Pascal U. and Craciun, Ioana and Gaitzsch, Jens and Weiner, Lev and Palivan, Cornelia G.. (2018) Delivery of ROS Generating Anthraquinones Using Reduction-Responsive Peptide-Based Nanoparticles. Helvetica Chimica Acta, 101 (7). e1800064.

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Official URL: https://edoc.unibas.ch/65320/

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Abstract

In order to limit the side effects associated with antitumor drugs such as doxorubicin, nanosized drug-delivery systems capable of selectively delivering and releasing the drug in the diseased tissue are required. We describe nanoparticles (NPs), self-assembled from a reduction responsive amphiphilic peptide, capable of entrapping high amounts of a redox active anticancer drug candidate and releasing it in presence of a reducing agent. This system shows a high entrapment efficiency with up to 15mg drug per gram of peptide (5.8mol-%). Treatment of the NPs with reducing agent results in the disassembly of the NPs and release of the drug molecules. A reduction in cell viability is observed at drug concentrations above 250nm in HEK293T and HeLa cell lines. This drug delivery system has potential for targeting tumor sites via the EPR effect while taking advantage of the increased reduction potential in tumor microenvironment.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan)
UniBasel Contributors:Palivan, Cornelia G
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0018-019X
e-ISSN:1522-2675
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:26 Sep 2018 10:57
Deposited On:05 Sep 2018 07:29

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