edoc

Reduced transmission of Mycobacterium africanum compared to Mycobacterium tuberculosis in urban West Africa

Asare, Prince and Asante-Poku, Adwoa and Prah, Diana Ahu and Borrell, Sonia and Osei-Wusu, Stephen and Otchere, Isaac Darko and Forson, Audrey and Adjapong, Gloria and Koram, Kwadwo Ansah and Gagneux, Sebastien and Yeboah-Manu, Dorothy. (2018) Reduced transmission of Mycobacterium africanum compared to Mycobacterium tuberculosis in urban West Africa. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 73. pp. 30-42.

[img] PDF - Published Version
Available under License CC BY (Attribution).

1923Kb

Official URL: https://edoc.unibas.ch/65191/

Downloads: Statistics Overview

Abstract

Understanding transmission dynamics is useful for tuberculosis (TB) control. A population-based molecular epidemiological study was conducted to determine TB transmission in Ghana.; Mycobacterium tuberculosis complex (MTBC) isolates obtained from prospectively sampled pulmonary TB patients between July 2012 and December 2015 were characterized using spoligotyping and standard 15-locus mycobacterial interspersed repetitive unit variable number tandem repeat (MIRU-VNTR) typing for transmission studies.; Out of 2309 MTBC isolates, 1082 (46.9%) unique cases were identified, with 1227 (53.1%) isolates belonging to one of 276 clusters. The recent TB transmission rate was estimated to be 41.2%. Whereas TB strains of lineage 4 belonging to M. tuberculosis showed a high recent transmission rate (44.9%), reduced recent transmission rates were found for lineages of Mycobacterium africanum (lineage 5, 31.8%; lineage 6, 24.7%).; The study findings indicate high recent TB transmission, suggesting the occurrence of unsuspected outbreaks in Ghana. The observed reduced transmission rate of M. africanum suggests other factor(s) (host/environmental) may be responsible for its continuous presence in West Africa.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Tuberculosis Research (Gagneux)
UniBasel Contributors:Borrell Farnov, Sonia and Gagneux, Sebastien
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1201-9712
e-ISSN:1878-3511
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:05 Sep 2018 10:04
Deposited On:05 Sep 2018 10:04

Repository Staff Only: item control page