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Acute changes in DNA methylation in relation to 24 h personal air pollution exposure measurements : a panel study in four European countries

Mostafavi, Nahid and Vermeulen, Roel and Ghantous, Akram and Hoek, Gerard and Probst-Hensch, Nicole and Herceg, Zdenko and Tarallo, Sonia and Naccarati, Alessio and Kleinjans, Jos C. S. and Imboden, Medea and Jeong, Ayoung and Morley, David and Amaral, Andre F. S. and van Nunen, Erik and Gulliver, John and Chadeau-Hyam, Marc and Vineis, Paolo and Vlaanderen, Jelle. (2018) Acute changes in DNA methylation in relation to 24 h personal air pollution exposure measurements : a panel study in four European countries. Environment international, 120. pp. 11-21.

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Official URL: https://edoc.unibas.ch/65071/

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Abstract

One of the potential mechanisms linking air pollution to health effects is through changes in DNA-methylation, which so far has mainly been analyzed globally or at candidate sites.; We investigated the association of personal and ambient air pollution exposure measures with genome-wide DNA-methylation changes.; We collected repeated 24-hour personal and ambient exposure measurements of particulate matter (PM; 2.5; ), PM; 2.5; absorbance, and ultrafine particles (UFP) and peripheral blood samples from a panel of 157 healthy non-smoking adults living in four European countries. We applied univariate mixed-effects models to investigate the association between air pollution and genome-wide DNA-methylation perturbations at single CpG (cytosine-guanine dinucleotide) sites and in Differentially Methylated Regions (DMRs). Subsequently, we explored the association of air pollution-induced methylation alterations with gene expression and serum immune marker levels measured in the same subjects.; Personal exposure to PM; 2.5; was associated with methylation changes at 13 CpG sites and 69 DMRs. Two of the 13 identified CpG sites (mapped to genes KNDC1 and FAM50B) were located within these DMRs. In addition, 42 DMRs were associated with personal PM; 2.5; absorbance exposure, 16 DMRs with personal exposure to UFP, 4 DMRs with ambient exposure to PM; 2.5; , 16 DMRs with ambient PM; 2.5; absorbance exposure, and 15 DMRs with ambient UFP exposure. Correlation between methylation levels at identified CpG sites and gene expression and immune markers was generally moderate.; This study provides evidence for an association between 24-hour exposure to air pollution and DNA-methylation at single sites and regional clusters of CpGs. Analysis of differentially methylated regions provides a promising avenue to further explore the subtle impact of environmental exposures on DNA-methylation.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Probst Hensch, Nicole and Imboden, Medea and Jeong, Ayoung
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0160-4120
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:05 Sep 2018 09:09
Deposited On:05 Sep 2018 09:09

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