edoc

Age-related brain structural alterations as an intermediate phenotype of psychosis

Dukart, Juergen and Smieskova, Renata and Harrisberger, Fabienne and Lenz, Claudia and Schmidt, André and Walter, Anna and Huber, Christian and Riecher-Rössler, Anita and Simon, Andor and Lang, Undine E. and Fusar-Poli, Paolo and Borgwardt, Stefan. (2017) Age-related brain structural alterations as an intermediate phenotype of psychosis. Journal of psychiatry & neuroscience, 42 (5). pp. 307-319.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/65003/

Downloads: Statistics Overview

Abstract

There is only limited agreement with respect to location, directionality and functional implications of brain structural alterations observed in patients with schizophrenia. Additionally, their link to occurrence of psychotic symptoms remains unclear. A viable way of addressing these questions is to examine populations in an at-risk mental state (ARMS) before the transition to psychosis.; We tested for structural brain alterations in individuals in an ARMS compared with healthy controls and patients with first-episode psychosis (FEP) using voxel-based morphometry and measures of cortical thickness. Furthermore, we evaluated if these alterations were modified by age and whether they were linked to the observed clinical symptoms.; Our sample included 59 individuals with ARMS, 26 healthy controls and 59 patients with FEP. We found increased grey matter volume and cortical thickness in individuals with ARMS and a similar pattern of structural alterations in patients with FEP. We further found stronger age-related reductions in grey matter volume and cortical thickness in both patients with FEP and individuals with ARMS, linking these alterations to observed clinical symptoms.; The ARMS group comprised subgroups with heterogeneous levels of psychosis risk and medication status. Furthermore, the cross-sectional nature of our study and the reduced number of older patients limit conclusions with respect to observed interactions with age.; Our findings on consistent structural alterations in individuals with ARMS and patients with FEP and their link to clinical symptoms have major implications for understanding their time of occurrence and relevance to psychotic symptoms. Interactions with age found for these alterations may explain the heterogeneity of findings reported in the literature.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
UniBasel Contributors:Schmidt, André and Riecher-Rössler, Anita
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Canadian Medical Association
ISSN:1180-4882
e-ISSN:1488-2434
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:21 Aug 2019 13:40
Deposited On:15 Aug 2018 16:32

Repository Staff Only: item control page