edoc

Revisiting Monomer Synthesis and Radical Ring Opening Polymerization of Dimethylated MDO Towards Biodegradable Nanoparticles for Enzymes

Gaitzsch, Jens and Welsch, Pascale C. and Folini, Jenny and Schoenenberger, Cora-Ann and Anderson, James C. and Meier, Wolfgang P.. (2018) Revisiting Monomer Synthesis and Radical Ring Opening Polymerization of Dimethylated MDO Towards Biodegradable Nanoparticles for Enzymes. European Polymer Journal, 101. pp. 113-119.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/64989/

Downloads: Statistics Overview

Abstract

Radical ring opening polymerization is a powerful tool to achieve a polyester via radical polymerization. We used it to obtain a dimethylated version of poly(caprolactone) (PdmCL) from dimethylated MDO (DMMDO). First, we revisited monomer synthesis and achieved a milder synthetic protocol by introducing a cobalt-based catalyst. We also developed a new route towards DMMDO via a cyclic carbonate using the Petasis chemistry. Amphiphilic block-copolymers were then generated by free radical polymerization of DMMDO with a PEG-based macroinitiator. The resulting polyesters self-assembled into nanoparticles that were biodegradable as well as biocompatible. The nanoparticles proved to be an effective protective shell for an entrapped enzyme that was released upon degradation of the polyester by esterase. We are confident that our results will spur further research into block-copolymers resulting from RROP.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0014-3057
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:02 Apr 2019 08:38
Deposited On:25 Jul 2018 10:26

Repository Staff Only: item control page