Maternal age at delivery, lung function and asthma in offspring : a population-based survey

Gómez Real, Francisco and Burgess, John A. and Villani, Simona and Dratva, Julia and Heinrich, Joachim and Janson, Christer and Jarvis, Debbie and Koplin, Jennifer and Leynaert, Bénédicte and Lodge, Caroline and Lærum, Birger N. and Matheson, Melanie C. and Norbäck, Dan and Omenaas, Ernst R. and Skulstad, Svein M. and Sunyer, Jordi and Dharmage, Shyamali C. and Svanes, Cecilie. (2018) Maternal age at delivery, lung function and asthma in offspring : a population-based survey. The European respiratory journal, 51 (6). p. 1601611.

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Official URL: https://edoc.unibas.ch/64934/

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There is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring's lung function, respiratory symptoms and asthma, and potential differences according to offspring sex.10 692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25-55 years. In logistic and linear multilevel mixed models we adjusted for participants' characteristics (age, education, centre, number of older siblings) and maternal characteristics (smoking in pregnancy, education) while investigating for differential effects by sex. Maternal age was validated in a subsample using data from the Norwegian birth registry.Increasing maternal age was associated with increasing forced expiratory volume in 1 s (2.33 mL per year, 95% CI 0.34-4.32 mL per year), more consistent in females (p; trend; 0.025) than in males (p; trend; 0.14). Asthma (OR 0.85, 95% CI 0.79-0.92) and respiratory symptoms (OR 0.87, 95% CI 0.82-0.92) decreased with increasing maternal age (per 5 years) in females, but not in males (p; interaction; 0.05 and 0.001, respectively). The results were consistent across centres and not explained by confounding factors.Maternal ageing was related to higher adult lung function and less asthma/symptoms in females. Biological characteristics in offspring related to maternal ageing are plausible and need further investigation.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Exposome Science (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Exposome Science (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Dratva, Julia
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Jul 2018 09:10
Deposited On:04 Jul 2018 09:10

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