Hemolysis after oral artemisinin combination therapy for uncomplicated plasmodium falciparum malaria

Kurth, Florian and Lingscheid, Tilman and Steiner, Florian and Stegemann, Miriam S. and Bélard, Sabine and Menner, Nikolai and Pongratz, Peter and Kim, Johanna and von Bernuth, Horst and Mayer, Beate and Damm, Georg and Seehofer, Daniel and Salama, Abdulgabar and Suttorp, Norbert and Zoller, Thomas. (2016) Hemolysis after oral artemisinin combination therapy for uncomplicated plasmodium falciparum malaria. Emerging infectious diseases, 22 (8). pp. 1381-1386.

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Official URL: https://edoc.unibas.ch/64781/

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Episodes of delayed hemolysis 2-6 weeks after treatment of severe malaria with intravenous artesunate have been described. We performed a prospective observational study of patients with uncomplicated malaria to investigate whether posttreatment hemolysis also occurs after oral artemisinin-based combination therapy. Eight of 20 patients with uncomplicated malaria who were given oral artemisinin-based combination therapy met the definition of posttreatment hemolysis (low haptoglobin level and increased lactate dehydrogenase level on day 14). Five patients had hemolysis persisting for 1 month. Patients with posttreatment hemolysis had a median decrease in hemoglobin level of 1.3 g/dL (interquartile range 0.3-2.0 g/dL) in the posttreatment period, and patients without posttreatment hemolysis had a median increase of 0.3 g/dL (IQR -0.1 to 0.7 g/dL; p = 0.002). These findings indicate a need for increased vigilance for hemolytic events in malaria patients, particularly those with predisposing factors for anemia.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Zoller, Thomas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Center for Infectious Diseases
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Jul 2018 12:23
Deposited On:04 Jul 2018 12:23

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