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Inflammation boosts bacteriophage transfer between Salmonella spp

Diard, Médéric and Bakkeren, Erik and Cornuault, Jeffrey K. and Moor, Kathrin and Hausmann, Annika and Sellin, Mikael E. and Loverdo, Claude and Aertsen, Abram and Ackermann, Martin and De Paepe, Marianne and Slack, Emma and Hardt, Wolf-Dietrich. (2017) Inflammation boosts bacteriophage transfer between Salmonella spp. Science, 355 (6330). pp. 1211-1215.

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Official URL: https://edoc.unibas.ch/64692/

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Abstract

Bacteriophage transfer (lysogenic conversion) promotes bacterial virulence evolution. There is limited understanding of the factors that determine lysogenic conversion dynamics within infected hosts. A murine; Salmonella; Typhimurium (; S; Tm) diarrhea model was used to study the transfer of SopEΦ, a prophage from; S; Tm SL1344, to; S; Tm ATCC14028S. Gut inflammation and enteric disease triggered >55% lysogenic conversion of ATCC14028S within 3 days. Without inflammation, SopEΦ transfer was reduced by up to 10; 5; -fold. This was because inflammation (e.g., reactive oxygen species, reactive nitrogen species, hypochlorite) triggers the bacterial SOS response, boosts expression of the phage antirepressor Tum, and thereby promotes free phage production and subsequent transfer. Mucosal vaccination prevented a dense intestinal; S; Tm population from inducing inflammation and consequently abolished SopEΦ transfer. Vaccination may be a general strategy for blocking pathogen evolution that requires disease-driven transfer of temperate bacteriophages.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Pathogen Evolution (Diard)
UniBasel Contributors:Diard, Médéric
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1095-9203
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:12 Feb 2019 16:52
Deposited On:12 Feb 2019 16:52

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