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Self-nanoemulsifying drug-delivery systems improve oral absorption and antischistosomal activity of epiisopiloturine

de Lima, Luiza Ianny and Py-Daniel, Karen Rapp and Guimarães, Maria Adelaide and Muehlmann, Luís Alexandre and Mafud, Ana Carolina and Mascarenhas, Yvonne Primerano and Moraes, Josué de and de Souza de Almeida Leite, José Roberto and Jiang, Cheng-Shi and Azevedo, Ricardo Bentes and Figueiró Longo, João Paulo. (2018) Self-nanoemulsifying drug-delivery systems improve oral absorption and antischistosomal activity of epiisopiloturine. Nanomedicine, 13 (7). pp. 689-702.

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Official URL: https://edoc.unibas.ch/64658/

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Abstract

To develop a self-nanoemulsifying drug-delivery system (SNEDDS) able to improve oral absorption of epiisopiloturine (EPI), and test the antischistosomal activity in a mice model.; SNEDDS had a nanoscopic size and was able to enhance EPI bioavailability after oral administration, and SNEDDS-EPI (40 mg.kg; -1; ) improved the in vivo antischistosomal activity of EPI, demonstrating that SNEDDS was able to improve the pharmacokinetics of EPI, and to maintain the pharmacodynamic activity against Schistosoma mansoni in vivo.; Taken together, these results indicate that SNEDDS-EPI is efficient in reducing worm burden in comparison to treatment with the free version of EPI. [Formula: see text].
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Helminth Drug Development (Keiser)
UniBasel Contributors:Mafud, Ana
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Future Medicine
ISSN:1743-5889
e-ISSN:1748-6963
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:03 Jul 2018 10:48
Deposited On:03 Jul 2018 10:48

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