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A virtual look at Epstein-Barr virus infection: simulation mechanism

Shapiro, M. and Duca, K. A. and Lee, K. and Delgado-Eckert, E. and Hawkins, J. and Jarrah, A. S. and Laubenbacher, R. and Polys, N. F. and Hadinoto, V. and Thorley-Lawson, D. A.. (2008) A virtual look at Epstein-Barr virus infection: simulation mechanism. Journal of Theoretical Biology, 252 (4). pp. 633-648.

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Official URL: https://edoc.unibas.ch/64027/

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Abstract

Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > P├Ądiatrie (Frey)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > P├Ądiatrie (Frey)
03 Faculty of Medicine > Departement Biomedical Engineering
UniBasel Contributors:Delgado-Eckert, Edgar
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0022-5193
e-ISSN:1095-8541
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:02 Dec 2020 15:25
Deposited On:02 Dec 2020 15:25

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