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Both melatonin and meloxicam improved sleep and pain in females with primary dysmenorrhea - results from a double-blind cross-over intervention pilot study

Keshavarzi, Farahnaz and Mahmoudzadeh, Fariba and Brand, Serge and Sadeghi Bahmani, Dena and Akbari, Fariba and Khazaie, Habibolah and Rasoul Ghadami, Mohammad. (2018) Both melatonin and meloxicam improved sleep and pain in females with primary dysmenorrhea - results from a double-blind cross-over intervention pilot study. Archives of Women s Mental Health.

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Official URL: https://edoc.unibas.ch/63414/

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Abstract

Up to 25% of ovulating women suffer from primary dysmenorrhea, a condition associated with pain and transient reduced quality of life, along with greater irritability and impaired sleep. In the present study, we asked whether and if so to what extent melatonin and meloxicam can improve subjective and objective sleep and reduce pain among women with primary dysmenorrhea. To this end we conducted a double-blind cross-over clinical trial lasting for three menstrual cycles. Method: A total of 14 women (mean age: M = 27.5 years) with primary dysmenorrhea took part in the study. At baseline, that is, during the first menstruation, they completed a visual analogue scale to rate pain; sleep continuity was assessed via actigraphs, and overall sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI). Next, participants were randomly assigned to one of two conditions, either melatonin during the second, and meloxicam during the third menstruation, or meloxicam during the second, and melatonin during the third menstruation. Neither participants nor investigators were aware of participants' study assignment. During the second and third menstruations, the assessments described above were repeated. Results: At baseline, sleep assessed both objectively and subjectively was impaired, and pain was high. Subjective sleep improved and pain decreased during the second and third menstruations irrespective of whether melatonin or meloxicam was administered first or second. Likewise, objective sleep efficiency increased and objective sleep latency shortened. The efficacy of melatonin was superior to that of meloxicam. Conclusions: The present pattern of results suggests that both melatonin and meloxicam are suitable to treat pain and PD-related sleep complaints among women with primary dysmenorrhea.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Klinische Stress- und Traumaforschung (Holsboer-Trachsler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Klinische Stress- und Traumaforschung (Holsboer-Trachsler)
UniBasel Contributors:Brand, Serge
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Apr 2020 18:04
Deposited On:27 Apr 2020 18:04

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