Chronic obstructive pulmonary disease and the risk of depression

Schneider, Cornelia and Jick, Susan S. and Bothner, Ulrich and Meier, Christoph R.. (2009) Chronic obstructive pulmonary disease and the risk of depression. Chest, 2009, epub ahead of print.

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Official URL: http://edoc.unibas.ch/dok/A5255147

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BACKGROUND: Chronic comorbidities are often associated with depression. Most previous studies exploring the association between COPD and depression were rather small and based on a cross-sectional study design. We conducted a large population-based study on the risk of developing an incident depression diagnosis in association with a previous COPD diagnosis. METHODS: We used the UK-based General Practice Research Database to assess and compare the prevalence of a history of depression, and to quantify the risk of developing incident depression in patients with COPD and COPD-free patients between 1995 and 2005. We conducted a nested case-control analysis, matching up to four patients who did not develop depression for each case patient with depression, to further analyze the impact of COPD severity. RESULTS: In a study population of 35,722 COPD patients and 35,722 COPD-free patients, the prevalence of diagnosed depression prior to the first COPD diagnosis was higher in the COPD population (23.1%) than among COPD-free patients (16.8%). The incidence rate of a new onset diagnosis of depression after the first COPD diagnosis was 16.2 / 1000 person-years (py) in the COPD group, while it was only 9.4 / 1000 py in the COPD-free comparison group. In the nested case-control analysis, patients with severe COPD had the highest risk of developing depression (OR 2.01, 95% CI 1.45-2.78). CONCLUSION: This large observational study provides further evidence that patients with COPD are at an increased risk of developing depression.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Klinische Pharmazie/Spitalpharmazie (Meier)
UniBasel Contributors:Meier, Christoph R. and Schneider, Cornelia
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American College of Chest Physicians
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:34

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