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Effects of Gestational Age on Brain Volume and Cognitive Functions in Generally Healthy Very Preterm Born Children during School-age: A Voxel-based Morphometry Study

Lemola, Sakari and Oser, Nadine and Urfer-Maurer, Natalie and Brand, Serge and Holsboer-Trachsler, Edith and Bechtel, Nina and Grob, Alexander and Weber, Peter and Datta, Alexandre N.. (2017) Effects of Gestational Age on Brain Volume and Cognitive Functions in Generally Healthy Very Preterm Born Children during School-age: A Voxel-based Morphometry Study. PLoS ONE, 12 (8, e0183519). pp. 1-13.

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Official URL: https://edoc.unibas.ch/63250/

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Abstract

To determine whether the relationship of gestational age (GA) with brain volumes and cognitive functions is linear or whether it follows a threshold model in preterm and term born children during school-age.; We studied 106 children (M = 10 years 1 month, SD = 16 months; 40 females) enrolled in primary school: 57 were healthy very preterm children (10 children born 24-27 completed weeks' gestation (extremely preterm), 14 children born 28-29 completed weeks' gestation, 19 children born 30-31 completed weeks' gestation (very preterm), and 14 born 32 completed weeks' gestation (moderately preterm)) all born appropriate for GA (AGA) and 49 term-born children. Neuroimaging involved voxel-based morphometry with the statistical parametric mapping software. Cognitive functions were assessed with the WISC-IV. General Linear Models and multiple regressions were conducted controlling age, sex, and maternal education.; Compared to groups of children born 30 completed weeks' gestation and later, children born <28 completed weeks' gestation had less gray matter volume (GMV) and white matter volume (WMV) and poorer cognitive functions including decreased full scale IQ, and processing speed. Differences in GMV partially mediated the relationship between GA and full scale IQ in preterm born children.; In preterm children who are born AGA and without major complications GA is associated with brain volume and cognitive functions. In particular, decreased brain volume becomes evident in the extremely preterm group (born <28 completed weeks' gestation). In preterm children born 30 completed weeks' gestation and later the relationship of GA with brain volume and cognitive functions may be less strong as previously thought.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Society & Choice > Entwicklungs- und Pers├Ânlichkeitspsychologie (Grob)
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Klinische Stress- und Traumaforschung (Holsboer-Trachsler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Klinische Stress- und Traumaforschung (Holsboer-Trachsler)
03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit > Bereich Sportwissenschaft > Sportwissenschaften (P├╝hse)
UniBasel Contributors:Urfer, Natalie and Grob, Alexander and Brand, Serge
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Public Library of Science
e-ISSN:1932-6203
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:23 Oct 2019 14:24
Deposited On:16 Jul 2018 14:21

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