edoc

Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology

Bhattacharyya, Sagnik and Morrison, Paul D. and Fusar-Poli, Paolo and Martin-Santos, Rocio and Borgwardt, Stefan and Winton-Brown, Toby and Nosarti, Chiara and O' Carroll, Colin M. and Seal, Marc and Allen, Paul and Mehta, Mitul A. and Stone, James M. and Tunstall, Nigel and Giampietro, Vincent and Kapur, Shitij and Murray, Robin M. and Zuardi, Antonio W. and Crippa, José A. and Atakan, Zerrin and McGuire, Philip K.. (2010) Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35 (3). pp. 764-774.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/63222/

Downloads: Statistics Overview

Abstract

Delta-9-tetrahydrocannabinol (Delta-9-THC) and Cannabidiol (CBD), the two main ingredients of the Cannabis sativa plant have distinct symptomatic and behavioral effects. We used functional magnetic resonance imaging (fMRI) in healthy volunteers to examine whether Delta-9-THC and CBD had opposite effects on regional brain function. We then assessed whether pretreatment with CBD can prevent the acute psychotic symptoms induced by Delta-9-THC. Fifteen healthy men with minimal earlier exposure to cannabis were scanned while performing a verbal memory task, a response inhibition task, a sensory processing task, and when viewing fearful faces. Subjects were scanned on three occasions, each preceded by oral administration of Delta-9-THC, CBD, or placebo. BOLD responses were measured using fMRI. In a second experiment, six healthy volunteers were administered Delta-9-THC intravenously on two occasions, after placebo or CBD pretreatment to examine whether CBD could block the psychotic symptoms induced by Delta-9-THC. Delta-9-THC and CBD had opposite effects on activation relative to placebo in the striatum during verbal recall, in the hippocampus during the response inhibition task, in the amygdala when subjects viewed fearful faces, in the superior temporal cortex when subjects listened to speech, and in the occipital cortex during visual processing. In the second experiment, pretreatment with CBD prevented the acute induction of psychotic symptoms by Delta-9-tetrahydrocannabinol. Delta-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD's ability to block the psychotogenic effects of Delta-9-THC.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Neuropsychiatrie (Borgwardt)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Neuropsychiatrie (Borgwardt)
UniBasel Contributors:Borgwardt, Stefan
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
ISSN:0893-133X
e-ISSN:1740-634X
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:10 Aug 2020 14:47
Deposited On:10 Aug 2020 14:47

Repository Staff Only: item control page