Szlam, Fania and Luan, Deyan and Bolliger, Daniel and Szlam, Arthur D. and Levy, Jerrold H. and Varner, Jeffrey D. and Tanaka, Kenichi A.. (2010) Anti-factor IXa Aptamer reduces propagation of thrombin generation in plasma anticoagulated with warfarin. Thrombosis Research, 125 (5). pp. 432-437.
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Official URL: https://edoc.unibas.ch/63124/
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Abstract
Warfarin is routinely used in the prevention and treatment of prothrombotic events. During initiation of warfarin therapy levels of factor (F) VII and protein C decrease rapidly but prothrombin, FIX and FX decline much slower. Therefore, propagation of thrombin generation (TG) remains unaffected much longer, increasing the risk of inadequate anticoagulation. Recently, a novel agent, anti-IXa aptamer, RB006, has been developed. Therefore, we have evaluated the in vitro effects of this agent in warfarin plasma.
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Ehemalige Einheiten Querschnittsfächer (Klinik) > Allgemeine Anästhesie (Scheidegger) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Ehemalige Einheiten Querschnittsfächer (Klinik) > Allgemeine Anästhesie (Scheidegger) |
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| UniBasel Contributors: | Bolliger, Daniel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Pergamon Press |
| ISSN: | 0049-3848 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 10 Aug 2020 13:30 |
| Deposited On: | 10 Aug 2020 13:30 |
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