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Mechanical nanosensor based on FRET within a thermosome : damage-reporting polymeric materials

Bruns, Nico and Pustelny, Katarzyna and Bergeron, Lisa M. and Whitehead, Timothy A. and Clark, Douglas S.. (2009) Mechanical nanosensor based on FRET within a thermosome : damage-reporting polymeric materials. Angewandte Chemie, Jg. 121, Nr. 31. pp. 5776-5779.

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Official URL: http://edoc.unibas.ch/dok/A5265392

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Abstract

Unter Spannung: Ändert sich in einem Protein-Polymer-Hybridmaterial die mechanische Spannung der Polymermatrix, so löst dies eine Konformationsänderung des Proteinkomplexes aus: Das Material meldet eine strukturelle Schädigung (siehe Bild). Die Reporterkomponente ist ein Chaperonin, das ein Paar fluoreszierender Proteine kovalent bindet. Wird das Chaperonin deformiert, ändert sich der Abstand zwischen den Fluorophoren und folglich auch das FRET-Signal. Under stress: Changes in stress of the polymer matrix in a protein-polymer hybrid material result in changes of conformation of the protein complex, thus resulting in a damage-reporting material (see picture). The reporter is an engineered chaperonin that covalently entraps a pair of fluorescent proteins. Deformation of the chaperonin leads to a change in fluorophore distance and a change in the fluorescene resonance energy transfer (FRET) signal.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Bruns, Nico
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-VCH
ISSN:0044-8249
Note:Also published in: Angewandte Chemie. International edition in English. - Weinheim : VCH. - Vol. 48, H. 31 (2009), S. 5666–5669 -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:34

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