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Altered prefrontal connectivity after acute heroin administration during cognitive control

Schmidt, André and Borgwardt, Stefan and Gerber, Hana and Schmid, Otto and Wiesbeck, Gerhard A. and Riecher-Rössler, Anita and Bendfeldt, Kerstin and Smieskova, Renata and Lang, Undine E. and Rubia, Katya and Walter, Marc. (2014) Altered prefrontal connectivity after acute heroin administration during cognitive control. International Journal of Neuropsychopharmacology, 17 (9). pp. 1375-1385.

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Abstract

Neuroimaging studies have reported reduced activity in a broad network of brain regions during response inhibition in heroin-dependent patients. However, how heroin in an acute dose modulates the neural correlates of response inhibition and the underlying brain connectivity has not yet been investigated. In this double-blind placebo-controlled study, we used functional magnetic resonance imaging to examine whether acute heroin administration changed whole brain activity during response inhibition in 26 heroin-dependent patients. We then applied dynamic causal modelling to investigate the effect of an acute dose of heroin on the functional interactions between the dorsal anterior cingulate cortex (dACC) and the bilateral inferior frontal gyri (IFG). Heroin acutely reduced dACC activity, as well as the inhibition-induced modulation of connectivity from the dACC to the right IFG compared with placebo. Furthermore, dACC activity was positively related to false alarm rates after placebo but not heroin administration. These results suggest that acute heroin administration impairs cognitive control in dependent patients by reducing the activity in the dACC activity and the functional connectivity from the dACC to the right IFG.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
UniBasel Contributors:Schmidt, André and Riecher-Rössler, Anita
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Oxford University Press
ISSN:1461-1457
e-ISSN:1469-5111
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:28 Mar 2019 11:27
Deposited On:28 Aug 2018 16:10

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